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  Faculty Profile

Temesgen Samuel, DVM, PhD

Department of Pathobiology College of VM, Nursing & Allied Health Patterson Hall Room A408, Tuskegee, AL 36088

Phone 334-724-4547

(Office) -4617 (Lab) Fax 334-724-4110

tsamuel@tuskegee.edu

Temesgan
 

Education

1990

1998

1999

2002

 



DVM

PhD

Staff-Scientist Post- doctoral

 



Addis Ababa University,

Ethiopia Hannover School of Veterinary Medicine, Germany Erlangen-Nuremberg University, Germany Burnham Institute for Medical Research, USA


Veterinary Medicine

Cell Mol Biol, parasitology

Cell Mol Biol, cancer research

Cell Mol Biol, cancer research

Research Interest

1. Molecular Determinants for the Bioactivity of Dietary Compounds: my laboratory is examining the molecular mechanisms through which dietary compounds, specifically flavonoids, exert their effect to prevent cancer cell growth. Signaling pathways that regulate the cell cycle, apoptosis, and NF-kB activation are primary targets of interest. Drug-diet interaction is special focus of our research.

2. Anti-cancer cell and anti-microbial activities of natural compounds: we examine the potential bioactivity of natural compounds of diverse origin using cancer cells and common bacterial pathogens as targets.

3. Collaborative Research: a special cross-disciplinary project launched in collaboration with colleagues at the College of Engineering, Tuskegee University, to derivatize single walled carbon nanotubes (SWCNT) and to coat them with anti-cancer or anti-microbial compounds that can later be used in various applications in vivo or in the environment.

Recent Publications

Santoro, M. M., Samuel, T., Mitchell, T., Reed, J. C., and Stainier, D. Y. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet, 39: 1397-1402, 2007.

Hyer, M., Samuel, T, and Reed, JC. The FLIP-Side of Fas Signaling. Clinical Cancer Research, 12: 5929-5931, 2006. (Review)

Samuel, T., Welsh, K, Lober, T., Togo, SH., Zapata, JM, and Reed, JC Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases. J Biol Chem, 281: 1080-1090, 2006.

Samuel, T., Okada, K., Hyer, M., Welsh, K., Zapata, J. M., and Reed, J. C. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res, 65: 210-218, 2005.

Wang, Z., Cuddy, M., Samuel, T., Welsh, K., Schimmer, A., Hanaii, F., Houghten, R., Pinilla, C., and Reed, J. C. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J Biol Chem, 279: 48168-48176, 2004.

Dohi, T., Okada, K., Xia, F., Wilford, C. E., Samuel, T., Welsh, K., Marusawa, H., Zou, H., Armstrong, R., Matsuzawa, S., Salvesen, G. S., Reed, J. C., and Altieri, D. C. An IAP-IAP complex inhibits apoptosis. J Biol Chem, 279: 34087-34090, 2004.

Samuel, T., Weber, H. O., and Funk, J. O. Linking DNA damage to cell cycle checkpoints. Cell Cycle, 1: 162-168, 2002. (Review)

 

 

 

Tuskegee University is accredited by the commission on Colleges of the Southern Association of Colleges and Schools (1866 Southern Lane, Decatur,
Georgia 30033-4097 - Telephone 404-679-4501) to award doctoral, professional, master's and bachelor's degrees.